In children affected by CID, a defect in one or more of these genes results in the absence or malfunction of a protein necessary for normal functioning of the immune system. The immune system relies on a large number of genes for its normal development. PID UK has a separate information leaflet devoted to the genetics of primary immunodeficiency, available on its website at Specialists in genetics and genetic counselling are also on hand to talk through the inheritance of CID with you if needed. It is caused by a mistake (or ‘mutation’) in a child’s genetic make-up. What causes it?ĬID is usually an inherited condition, passed on in families in a similar way to physical characteristics, such as eye colour. Treatment is now available that can reduce the risk of serious infection, manage autoimmunity or overgrowth of white blood cells and, in some cases, cure the disorder. They are also important in controlling inflammation and preventing cancer. If T cells are completely missing then severe CID (SCID) results, producing a characteristic pattern of illness in babies – a separate leaflet is available about SCID available at This leaflet describes some of the common clinical features of CID in children. Not all patients are affected in the same way and sometimes the diagnosis is not made until adulthood. T cells are essential for protection against many infections: viruses, bacteria and fungi. Antibody production is usually also impaired, which is why the term ‘combined’ is used. The major problem in CID is that specialised white blood cells, known as T cells, do not function properly or there are not enough of them. This leaflet is designed to help answer the questions families may have about the immune condition called combined immunodeficiency (CID). It has been produced jointly by PID UK and the paediatric immunodeficiency centres at Great Ormond Street Hospital (GOSH) and the Great North Children’s Hospital.Combined immunodeficiency (CID) is the name given to a group of rare, inherited disorders of the immune system.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |